Genomics: A Grand Challenge for Medical Science and Technology

Genomics: A Grand Challenge for Medical Science and Technology

By Pharma Tech Outlook | Thursday, November 15, 2018

Genome evolution is a regular changing and evolving field due to the steadily growing number of sequenced genomes available to the scientific community and the public at large. Genome evolution is the process in which a genome varies in structure or size over time. The size of the genome is measured in base pairs. Thegene number determines the size of the prokaryotic genome.

A team of scientists has been working to integrate the largest genome, which consists of about 12 million base pairs arranged in 16 chromosomes that are structurally comparable to those of humans. The next synthetic step to this is to write the human genome. Such a project would create a wealth of information that connects DNA code to function. It would widen our understanding of how cellular systems work.

DNA sequencing was brand new when the Human Genome Project (HGP) was proposed. Reading a few hundred bases of the genetic code was hard and slow work. Despite criticism and skepticism, HGP-read was a booming success; it was declared complete a full two years early and under budget. Then, sequencing technology has become advanced and is widely used in research, as well as human and animal health. In retrospect, the early proponents of HGP were visionaries and pioneers. HGP remains the biggest collaborative project ever done in life science.

Autodesk’s Bio/Nano Research group has been examining and producing tools for designing the imagined world of molecular and cellular systems in the last few years. Reproducing the human genome could offer personalized medicine more affordable and accessible. It could also direct to 3D-printed organs for transplantation, virus- and aging-resistant cell lines, and to produce synthetic vaccines.

Synthetic biology field is more than 15 years old and moving incredibly fast. It’s exposing a gateway to making designer organisms. Synthetic biology is incredibly important and will eventually touch everything from health to manufacturing, and to national security. The synthetic biology’s potential is to shape the future, which is achieved by computers. The field is yet to be discovered. And what it needs is a breakout time, something that will get it remarked, something that will get people involved enough to bother.

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