How Can Collapsible Basket Technology Help Improve Drug Discovery?

Pharma Tech Outlook: Pharma Tech Magazine

How Can Collapsible Basket Technology Help Improve Drug Discovery?

By Pharma Tech Outlook | Wednesday, August 19, 2020

Improving drug discovery has become a big challenge for the pharma industry. Therefore, scientists have developed collapsible basket technology for enhancing drug discovery and customized medicine.

FREMONT, CA: To develop one FDA approved drug, drug discovery scientists has to screen up to 10,000 compounds in the initial stages. The candidate compounds are first tested on cell and tissue samples during this high-throughput screening.

Top 10 Drug Discovery and Development Consulting/Service Companies - 2019These kinds of experiments are conducted by using so-called multi-well plates, where every well serve as a test tube. Most of the initial screening process is automated. However, a significant exception is retrieving the cell and tissue samples from multi-well plates, generally 96 or more wells per plate, for further assessment in a microscope for histological analysis.

Recently, researchers of Purdue University have come up with a collapsible basket technology for speeding up the process of retrieving the cell and tissue samples for histology analysis. This significantly facilitates the evaluation process when drug discovery scientists are developing new drugs or when health care professionals are looking for the finest medicines for a given patient.

The collapsible basket array technology offers significant benefits for drug discovery and personalized medicine. The technology speeds up the procedure of creating new drugs by eradicating a time-consuming process step and decreases the error rate during cell and tissue transfer. The technology is specifically compatible with emerging technology for pharmacology, toxicology, cell biology, and customized medicines, 3D cell culture, where cells develop in 3D configuration better replicating patient tissues. The 3D cell cultures provide scientists with a more precise analysis of drug reactions in the body.

The technology is designed to combat the hurdles associated with managing and analysis of 3D culture. Those processes are generally laborious, majorly manual, and with low throughput. Raising the throughput can be advantageous to both drug discovery and personalized medicine.

The collapsible basket range is designed to be reconfigurable for great throughput culture and histological analysis, which includes studying the tissue and any related diseases. Doctors and scientists generally make use of such analysis for studying patients with cancer for better-examining tumors.

see also: Top Medtech Material Providers

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