How Can Molecular Drills Annihilate the Deadly 'Superbugs'?

Pharma Tech Outlook: Pharma Tech Magazine

How Can Molecular Drills Annihilate the Deadly 'Superbugs'?

Pharma Tech Outlook | Friday, July 17, 2020

The molecular drills have gained the ability to pinpoint and destroy deadly bacteria that have evolved resistance to almost all the antibiotics.

FREMONT, CA: According to the researchers at Rice University, Biola University, Texas A&M University, and Durham (U.K.) University showcased that motorized molecules developed in the lab are capable of killing antibiotic-resistant microbes within minutes. These superbugs can kill 10 million people each year by 2050, overtaking cancer as well; they do not respond to anything. The motors target the bacteria and, when activated with light, burrow past their exteriors.

Bacteria have evolved to have a resisting power against antibiotics by locking it out, but the bacteria have no defense against molecular drills. The medicines that are able to get through the openings made by drills are once again lethal to the bacteria. Few researchers in their paper introduced molecular drills for boring through cells in 2017, and these drills are paddlelike molecules that can be prompted to spin at 3 million rotations every second when it is activated with light.

Tests were conducted by the Texas A&M lab, where it killed Klebsiella pneumonia within minutes. The microscopic images of the targeted bacteria showed where the motors had drilled through cell walls. These bacteria have more than a layer; they have two bilayers and proteins with sugars that interlink them. Henceforth, things do not get through these robust cell walls. This is the reason why bacteria are complicated to kill. They do not have a way to defend against a machine like these molecular drills, as it is a mechanical action and not a chemical effect.

These motors additionally increase the susceptibility of K. pneumonia to meropenem, an antibacterial drug to which the bacteria had developed resistance. When the bacteria figure out a drug, it does not allow it to get in, and sometimes the bacteria defeat the drug by letting it in and then deactivating it.

The researchers could kill 94 percent of the pneumonia-causing pathogen after balancing motors and the antibiotics. The nanomachines might witness the immediate date impact in treating skin, catheter aureus, and wound implants the infections caused by the bacteria.

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