Single-use technologies can lower overall environmental impact like cutting down cleaning and being cost-effective compared to traditional systems.
FREMONT, CA: Since years, pharmaceutical manufacturers were investing in rigid stainless steel equipment for upstream processing. Although this traditional approach was beneficial in the past, it cannot hold up today. The introduction of new and innovative single-use containment products in the market has allowed manufacturers to access safe, flexible, and cost-effective solutions. Here are the benefits of using single-use containment products for upstream biopharmaceutical processes.
According to a study conducted by GE Healthcare in 2014, single-use technologies bring less environmental damage to other traditional systems. Preferring single-use technologies to stainless steel processes in pharmaceutical manufacturing was found to reduce the damage to human health, ecosystems, and resources. There is no need for cleaning as in stainless steel plants that uses not only excess water but also detergents and solvents. While it is difficult to disinfect water contaminated by drug products or cleaning chemicals, manufacturers, particularly in the U.S., choose the incineration process to dispose of this water.
There are a number of risks involved while handling hazardous drug products. Workers do not take into account the risks and carry out the routine tasks of transferring substances in open processes, causing powders to spread throughout the room, thereby damaging other materials or equipment and posing risks to employees. This kind of contamination can be a significant issue for biopharmaceutical plants, especially for those working with various products. Upstream processing involves taking a specific amount of powder or siloed materials and then transferring and loading into a hydration tank. It revolves around the ability to reduce the overall risk of bacteria and contamination.
With single-use products, the ability to handle the media powders and make dust type connections at the hydration tank is much better than with stainless steel equipment. Some products like ILC Dover’s EZ BioPac reduce dispensing times, stop spillage, and mitigate contamination risks. It is designed specially to reduce contamination in the powder transfer process. It possesses an outer skirt that folds down around the frame and then back up again, thus, providing a barrier between the outside of the bag and the product. It protects the powder from being transferred from the dispensing area to the process area.
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