How To Leverage the Power Of Nanoparticles in Melanoma?
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How To Leverage the Power Of Nanoparticles in Melanoma?

By Pharma Tech Outlook | Wednesday, November 06, 2019

Nano-vaccine surpasses the power of traditional methods, including chemotherapy, surgery, radiation therapy, and so on, to treat cancer.

Fremont, CA: One of the recent researches by cancer.net has proved that skin cancer has been the reason for most deaths this year alone. Nanomedicine is the technology that uses particles of the size, which is one-billionth of a meter for diagnosis and treatment. Irrespective of its small nature, these nanoparticles have the potential to fight against diseases, illnesses, and disabilities, such as cardiovascular disease, HIV, injuries, and so on. The war against cancer is universal, and it has failed to obtain the desired result through a variety of treatment modalities, including chemotherapy, radiation therapy, surgery, and immunotherapy. Recently, nanomedicine was employed to treat the most serious of skin cancers, melanoma, through improved detection, prevention, and treatment of the disease.

In the event of protecting the skin from the high exposure to ultraviolet rays produced by the sun, melanocytes will produce more melanin pigment. When it is synthesized uncontrollably, it can cause invasive melanoma of the skin. Recently, Tel Aviv researchers have developed a nano-vaccine for melanoma. The vaccine enhances the anti-cancer effect of the immunotherapy that inhibits tumor growth. The researchers harnessed nanoparticles of size 170 nanometers made of a biodegradable polymer. Each particle contained two peptide chains—HLA I and HLA II— that are expressed in melanoma cells. The infused nanoparticles stimulate the immune system by triggering the immune cells to identify and attack melanoma cells.

The nano vaccine has been proven effective in preventing and treating both primary tumors and diseases. The body’s immune system has learned to identify melanoma cells and specifically attack them. When injected, two different results were encountered. In one scenario, the vaccine prevented the disease from developing. In another, the vaccine and immunotherapy treated melanoma.

Although it was primarily tested on mice, when employed on human beings, the vaccine delayed the progression of the disease and extended their lives. The new treatment opens doors to a completely different approach—the nano vaccine approach—to effectively treat melanoma, even in the advanced stages of the disease.  

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