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The future of vaccine development will look bright if laboratory experimentation is combined with immunoinformatics techniques.
FREMONT, CA: The use of vaccines has resulted in a remarkable improvement in public health. It has saved several lives, lowered treatment costs, and scaled the quality of lives. Current vaccines came empirically with either vague or completely no knowledge of how they modulate the immune system. The concerns related to that have driven immunologists toward research for a better approach to vaccine development. Presently, immunoinformatics has paved the path for a better understanding of infectious disease pathogenesis, diagnosis, immune system response, and computational vaccinology. Read on to know more.
Discoveries in immunology combined with knowledge of bioinformatics tools for epitope predictions have resulted in the emergence of a new vaccine design pattern. The art of efficient and comprehensive data extraction and data analysis deposited in relevant databases is now essential in research related to immunology. With computational immunology techniques, it is easy to discover vaccine candidate simply by scanning the protein sequences in a pathogen of interest. Several of these proteins are yet to be isolated. Being pathogens specific and unique, they present ready candidates in vaccine development.
The need to use immunoinformatics-based tools is to unveil vital determinants of immunity made available in the genome sequence database and design vaccines. There is also a need to focus on novel computational, experimental, and computation-driven experimental methods for studying host-pathogen interactions, making it useful in vaccine development. There is a need for new approaches for effective drugs or vaccine design to tackle some pathogens' antigenic variability.
There has been an explosion of immunological data due to increased research to understand the immune system pathway in infectious disease pathogenesis. The application of bioinformatics knowledge has led to a better exposition of the immune system through immunoinformatics.
With the knowledge of the immune system and the cost-effective approach like immunoinformatics, the concerns for emerging diseases caused by pathogenic organisms, antigenic variability, and the need for personalized vaccination can be managed on a molecular level.