Unchained Labs Launches the New Hound for Particle Identification

Unchained Labs Launches the New Hound for Particle Identification

By Pharma Tech Outlook | Tuesday, July 30, 2019

The chemical and elemental particle identification solution will enable researchers, scientists, and manufacturers to seamlessly locate and identify particles in their products.

FREMONT, CA: In the drug development sector, the presence of unwanted particles can significantly reduce the quality of the drug, and can even lead to the shutdown of production. To overcome this problem, Unchained Labs recently launched a chemical and elemental particle identification platform—Hound. The one-of-a-kind solution integrates microscopy, Raman and Laser-Induced Spectroscopy (LIBS) to identify particles by their chemical and elemental fingerprints forensically.

Based in Pleasanton, CA, the life sciences company aims to deliver the best tools to biologics researchers, enabling them to ensure enhanced particle identification and quality control capabilities. The Hound is designed to free them from the shackles of antiquated technology, unleashing a robust range of problem-solving capabilities. The new Hound is the upgrade of Unchained Labs’ existing technology, which was already highly valued by its customers. The hardware and software have been enhanced, making the platform easy to use.

The Hound possesses the ability to identify a range of particles in a sample. The two Raman lasers and LIBS will enable the users to obtain a specific signature for any contaminants in a matter of minutes. Armed with the capabilities of the Hound, researchers will be able to tell if the rogue particles are protein, cellulose, protein, metal, or something else. The Hound can also identify chemical fingerprints for a broad range of organics such as fibers and protein aggregates using red and green Raman. It leverages LIBS to locate inorganic particles like glass and metal fragment, and identify them based on their elemental makeup.

It automatically spots the snagged particles using bright-field or dark-field. It scans the round and then reports the size and shape of every particle to the user. The fingerprints are matched with a customizable reference database. Users can also leverage the inbuilt tools to run a forensic sweep of the evidence.

Manufacturers can prepare their sample for various tests on the Hound. The platform captures particles by plucking them from the solution, or by using a filter round. The sample can be pipetted onto a wet round and kept covered to keep the blob suspended. The gold-coated surfaces are designed to catch the particles and cut the background noise.

Discovering foreign particles in their products after the production stage is the worst nightmare for any manufacturer and Unchained Labs aims to resolve that issue with the Hound.

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