What are the Significant Technology Trends in the Drug Discovery...
pharmatechoutlook

Pharma Tech Outlook: Pharma Tech Magazine

What are the Significant Technology Trends in the Drug Discovery and Development Field?

By Pharma Tech Outlook | Monday, August 10, 2020

There have been constant technological advancements in the drug discovery and development sector in recent years. How does it impact the pharma industry?

FREMONT, CA: Rapid advancements in pharma and biopharma drug development are leading to an increased number of intricate and niche therapies. This technological evolution is affecting manufacturing processes as well as equipment requirements. Demand for flexibility continues to remain the driving force behind the modern equipment. Small batches of specialized drug products, like highly cytotoxic and potent drugs that need containment, numerous drug delivery systems, digitization, and constant manufacturing, are amongst the primary factors impacting manufacturing and equipment. The following is a rundown of some of the modern pharma and biopharma trends.

Emerging Pharma/Biopharma Trends

Top 10 Drug Discovery and Development Solution Companies - 2019The constant evolution from the mainstream, mass-generated pharmaceuticals to more specialized therapies have needed an entire concept change in manufacturing and processes from pharma enterprises. Pharmaceutical companies that make small quantities require flexible machines that are capable of processing small batch sizes and distinct container kinds. Simultaneously, it is vital to retain the requirements of a high level for product quality and safety of the patient.

As an outcome, the demands on the flexibility of equipment systems are proliferating.

In the meantime, eradicating the risks associated with the exposure to considerably potent or cytotoxic drugs need high containment equipment solutions. One of the significant trends in the past few years has been unprecedented growth in the number of molecules being categorized as potent, mainly driven by the oncology market, as well as therapy domains involving pain and CNS disorders. These kinds of molecules need special handling to shield operators as well as the environment. However, some guidelines, including those issued by the International Society for Pharmacoepidemiology (ISPE), says that the best and preferred practice solutions should comprise contained engineering equipment whereby the molecules are subject to complete containment by using the technology.

The pharmaceutical industry is transforming and evolving at a remarkable pace. On the one hand, vital developments are taking place in biologics. On the other hand, the development of constant manufacturing equipment for oral solid dosage (OSD) is opening more potential for optimum API dosage and quicker time-to-market. In addition, digitization is making its debut in pharmaceutical production gradually and is on the verge of transforming the way the pharma industry work significantly.

Intricate Capabilities

Biopharma and pharma enterprises are increasingly looking for capabilities and services that can span research and development to manufacturing, filling, and packaging. Addressing the requirement for small to large scale manufacturing, isolator technology, incorporation options for different dosage forms, all while saving time and space, leads to increasingly intricate and versatile equipment.

Biopharma/pharma companies are also giving thought to manufacturing as well as packaging formats, specifically for biologics. The latest biologic development requires flexible equipment that is capable of handling smaller batches simultaneously, adapting to the latest products and packaging formats rapidly.

Innovations in Equipment

With the increasing number of biopharmaceuticals on the market, product, and operator security has become increasingly imperative. Great strides have been made by equipment manufacturers when it comes to the containment of highly cytotoxic and potent compounds. There have been significant advancements in technology in recent years, with the manufacturers continually evolving the available solutions. The field of contained engineering solutions whereby the molecules are completely contained at each stage of the process, thus minimizing the risk of exposure to the operators, and the environment is most probably one of the considerable developments. This, together with geometrically identical equipment to help scale-up and reproducibility, has transformed the way the potent molecules are managed.

The requirement for small-batch equipment with the right containment has also evolved along with the high potency of drugs, in the production of oral solid dose forms (OSD).

Enormous advancements have been made in the field of capsule filling with respect to smaller footprints, decreased expenses, and increased yield. While the latest equipment innovation is drastically enhancing manufacturing processing, demand for all-encompassing flexibility continues.

see also: Top MedTech Companies in USA

Weekly Brief

Read Also